Let me rephrase your question: "Please explain all of few body nuclear physics from the 1930's to the current program at:
https://www.jlab.org
https://web.mit.edu/lns/research/bates.html
and maybe
https://www.anl.gov
https://lpsc.in2p3.fr/index.php/en/le-lpsc
https://www.psi.ch/en
And two with "meson" in the name:
https://discover.lanl.gov/publications/1663/september-2022/50-years-of-beaming/
https://www.triumf.ca
IDK, I was just listed a few places I've been.
Anyway: mesons and baryons came first. Baryons are fermions, mesons are boson. Fermions exchange bosons in field theories, so that's it.
It's been called "Quantum Hadrodynamics" and is ofc an effective field theory--though I don't see that used much anymore.
One correction: it's not just pion exchange, it's all the mesons that fit. See: http://www.scholarpedia.org/article/Nuclear_Forces
This is not a history site, so I'll keep it short: the quark model and deep inelastic scattering at https://www6.slac.stanford.edu (and other labs) on the experiment side brought it all together.
tl;dr: Your question is too big...you could write a book on it. I don't even know how to give a short answer that does medium energy nuclear physics any justice.
Edit (per comment from OP):
Regarding whether the low energy hadron field theory is derivable from first principles QCD with the known quarks: no. I am not familiar with the state-of-the-art lattice-QCD, but I have never seen say, a deuteron model (that would be cool, tho).
The problem is: QCD is strong, non-abelian, and quantum, for the intractabilty trifecta.
Now Walter Greiner did QED in the strong regime--I'm not sure if it was many-body condensed matter or high $Z$ regions (at $Z=137$, $\alpha Z \approx 1$ and QED is no longer perturbative--irrc), or both. See https://www.semanticscholar.org/paper/Quantum-electrodynamics-of-strong-fields-Reinhardt-Greiner/15fade4903542eb2adaf58ff731ca7cad9898d5d for example. So here you can learn about the challenges of quantum field theory in the strong regime.
Okun has an old and wonderful book (https://www.amazon.com/Books-Introduction-Gauge-Theories/s?rh=n%3A283155%2Cp_28%3AAn+Introduction+to+Gauge+Theories) on the 100 years it took us to take curio of gauge invariance in EM to it being the fundamental symmetry of all the SM forces. In it, he talks about the classical chromodynamic treatment of a flavorless meson, a $q\bar q$ pair...he discusses the what the non-abelian field does, and it is complicated, as it's an 8 dimensional coupled color-"electric" field (and the complimentary 8 dimensions color-"magnetic" fields are not weak in comparison).
(That is a difficulty in just studying excited states of the nucleon, e.g. $N^*$ and $\Delta$...the spin-orbit coupling is not small compared with the charge/anti-charge force).
Regarding both the above examples, I was just an experimentalist, but sat through many theory seminars on such considerations--a long time ago.
So even your restricted question requires research programs to answer in any quantitative manner.