Two protons with the same quantum numbers (other than spin) will have completely overlapping wavefunctions, and thus will have greater strong force interaction between them and stronger binding energy.
This makes it energetically favorable (having lower energy) for protons to pair in pairs of opposite spins.
In particle physics, a fermion is a particle that follows Fermi–Dirac statistics. These particles obey the Pauli exclusion principle. Fermions include all quarks and leptons, as well as all composite particles made of an odd number of these, such as all baryons and many atoms and nuclei. Fermions differ from bosons, which obey Bose–Einstein statistics.
A fermion can be an elementary particle, such as the electron, or it can be a composite particle, such as the proton. According to the spin-statistics theorem in any reasonable relativistic quantum field theory, particles with integer spin are bosons, while particles with half-integer spin are fermions.
In addition to the spin characteristic, fermions have another specific property: they possess conserved baryon or lepton quantum numbers. Therefore, what is usually referred to as the spin statistics relation is in fact a spin statistics-quantum number relation.[1]
As a consequence of the Pauli exclusion principle, only one fermion can occupy a particular quantum state at any given time. If multiple fermions have the same spatial probability distribution, then at least one property of each fermion, such as its spin, must be different.
Please see here:
https://en.wikipedia.org/wiki/Fermion