Suppose we have two isolated non-conducting spheres with charges say, $Q_1$ and $Q_2$ respectively, and their centres are separated by a distance of $R$, to calculate the forces between them, we just do
$F=\frac{k.Q_1.Q_2}{R^2}.$
Basically we assume them to be point charges kept at their centre and then calculate the forces of those point charges. Now, I know electric field of any of the spheres resembles that of a point charge but for finding the force it's not obvious to assume the other sphere to be a point charge, and multiply the electric field with the other sphere's charge. Similar thing we do while calculating the potential energy of the system.
How can we assume the spheres to be point charges for any practical purposes? Is it just the result that we get after NOT assuming them to be point charges and calculating the force through integration?