The quick answer is that yes, it does make sense, if we interpret symmetric to mean self-adjoint. Symmetry of a bilinear form $g$ (or higher rank tensor) means $g(X,Y)=g(Y,X)$, but symmetry of a linear operator $A$ means $\langle X,A(Y)\rangle = \langle A(X),Y\rangle $ where the brackets denote some chosen inner product. In that sense, symmetry of a linear operator requires an inner product structure.
When we say that an operator is symmetric when it equals its transpose, we are (as pointed out by Michael Seifert's comment) making a category error. However, this can be understood as saying that $A$ and $A^\mathrm T$ are equal component-wise. While this does not strictly require an inner product, it is equivalent to choosing one and then expressing the components of $A$ and $A^\mathrm T$ in an orthonormal basis.
Before I climb up onto my soapbox for the long answer, it's important to make the point that I'll be talking about linear maps - functions between vector spaces, with a given domain and a given codomain. I distinguish this from a matrix, which is just a rectangular array of numbers which provides a convenient way to organize the components of a linear map in some given basis.
The long answer goes as follows:
Transpose
Let $V$ and $W$ be vector spaces and $V^*$ and $W^*$ their algebraic duals - that is, the set of linear maps from $V$ and $W$ to $\mathbb R$ (the extension to $\mathbb C$ is straightforward).
Given a linear operator $A:V\rightarrow W$, we define its transpose $A^\mathrm T:W^* \rightarrow V^*$ as follows. For every $\omega\in W^*$ and $v\in V$,
$$(A^\mathrm T \omega)(v) := \omega\big(Av)$$
In component notation,
$$(A^\mathrm{T})_i^{\ \ j} \omega_j v^i = \omega_j A^j_{\ \ i} v^i \iff (A^\mathrm T)_i^{\ \ j} = A^j_{\ \ i}$$
If we arrange the components of $A$ and $A^\mathrm T$ in rectangular grids and let the first index be the "row" index and the second be the "column" index, then the grid form of $A^\mathrm T$ is just the grid form of $A$ turned on its side.
Note that $V$ and $W$ could be completely different spaces of different dimensions; in array form, $A$ is generically an $n\times m$ matrix and $A^\mathrm T$ is then an $m\times n$ matrix.
Adjoint
Until now, $V$ and $W$ have been bare vector spaces with no additional structure. Now we specialize to the case where they are both Hilbert spaces, equipped with inner products $\langle \cdot,\cdot\rangle_V$ and $\langle \cdot,\cdot \rangle_W$ respectively. We also assume that they are finite-dimensional, as the infinite-dimensional case comes with substantial technical subtleties. Given a linear operator $A:V\rightarrow W$, we define its adjoint $A^\dagger: W\rightarrow V$ as follows. For every $v\in V$ and $w\in W$,
$$\langle A^\dagger w, v\rangle_V = \langle w, A v\rangle_W$$
In component form, if the inner products are given by metric tensors $(g_V)_{ij}$ and $(g_\mathrm W)_{ij}$, we have
$$(g_V)_{i\ell}(A^\dagger)^i_{\ \ j}w^j v^\ell = (g_W)_{ji} w^j A^i_\ell v^\ell \iff (A^\dagger)^i_{\ \ j} = (g_V)_{j\ell} A^\ell_{\ \ m}(g_W)^{mi}$$
or in matrix multiplication form,
$$(A^\dagger)^i_{\ \ j} = \left(g_V \cdot A \cdot g_W^{-1}\right)_j^{\ \ i}$$
Relationship between $A^\mathrm T$ and $A^\dagger$
To summarize so far, the transpose of a linear map always exists, requiring no extra structure to define, while the adjoint requires Hilbert space structures.
When the adjoint exists, it is related to the transpose in the following way. For the moment, I restrict my attention to linear operators $A:V\rightarrow V$ on a single Hilbert space; the generalization $A:V\rightarrow W$ is conceptually straightforward.
The inner product defines a canonical isomorphism between $V$ and $V^*$; to each vector $v\in V$ we associate a dual vector $\tilde v \in V^*$ where
$$\tilde v := \langle v,\bullet\rangle$$
In component form, $\tilde v_i = g_{ij} v^j$. Given this bijection, we can now state the relationship between the transpose and adjoint:
$$A^\mathrm T \tilde v = \langle A^\dagger v,\bullet\rangle$$
In component form,
$$(A^\mathrm T)_i^{\ \ j} = g_{i\ell} (A^\dagger)^\ell_{\ \ k} g^{kj}$$
and in matrix form,
$$A^\mathrm T = g \cdot A^\dagger \cdot g^{-1}$$
In other words, the action of the transpose on a dual vector can be understood as first raising the index on the covector, then acting on it with $A^\dagger$, and finally lowering the index again.
As an important note, if we choose an orthonormal basis such that $g_{ij}=\delta_{ij}$, then the components of the transpose are numerically equal to the components of the adjoint. For example, $(A^\mathrm T)_1^{\ \ 2} = (A^\dagger)^1_{\ \ 2}$. If we use the row-column convention for writing out these components in square arrays, then the matrix representations of these operators are identical - but it's important to remember that (i) this assumes that the basis in question is orthonormal, and (ii) we should not confuse the operators with their components.
What is Symmetry?
There are several definitions of symmetry which are usually quite closely related.
A linear operator on a (finite-dimensional) vector space equipped with an inner product is called symmetric if $A= A^\dagger$. In physics, we often call such operators "hermitian," especially in quantum mechanics.
On the other hand, in elementary linear algebra we usually define a linear operator $A:V\rightarrow V$ as being symmetric if $A=A^\mathrm T$. However, note that based on the formalism developed above, that doesn't make sense; $A$ and $A^\mathrm T$ act on different spaces. However, since $V$ and $V^*$ are isomorphic and a choice of basis $\{\hat e_i\}$ for $V$ induces a choice of basis $\hat \{\epsilon^i\}$ on $V^*$ such that $\hat \epsilon^i(\hat e_j)= \delta^i_j$, we may define $A$ as symmetric if $A$ and $A^\mathrm T$ are equal component-wise. That is, they are not the same as maps, but they have the same components as long as we choose canonically-related bases $\{\hat e_i\}$ and $\{\hat \epsilon^i\}$ for the two spaces.
Finally, a bilinear form $g$ is symmetric if, for all vectors $v,w\in V$, we have that $g(v,w)=g(w,v)$. In component form, this is just the statement that $g_{ij}=g_{ji}$.