Q1. The potential difference or voltage $V$ between two points is defined as the work required per unit charge to move the charge between the two points, or $V=W/Q$.
When work is done to move change between two points there is a change in electrical potential energy of the charge.
Q2. Based on the definition of voltage, $\Delta V$ would mean the change in voltage or change in work required per unit charge to move the charge between the two points.
For example, let’s say a current of 1 ampere flows in a 1 Ohm resistor. Per Ohm’s law the voltage between the terminals of the resistor equals 1 volt. If I increase the current to 4 amperes the voltage will be 4 volts. By increasing the current the change in voltage is 3 volts, or $\Delta V$ = 3 volts.
Q3. Work equals the change in potential energy.
Hope this helps.