The figure 4.2 sigma means that the discrepancy between the two numbers is 4.2 times the estimated standard deviation of the difference between the two numbers, under the assumptions that the measurements are independent and the uncertainties have an approximately normal distribution.
If I have two measurements $a \pm b$ and $c \pm d$, where $b$ and $d$ are the standard deviations corresponding to the uncertainties in $a$ and $c$, then standard error propagation theory tells me that the standard deviation of $a-c$ is $\sigma =\sqrt{b^2 + d^2}$.
In this case $a-c$ is different from zero by 4.2 times that standard deviation.
Qualitatively, the larger this multiple is then the more significantly the difference between $a$ and $c$ is from zero (i.e. that $a$ and $c$ are different).
Quantitatively, we look at the properties of the normal distribution function and ask: if the distribution is centred at $4.2\sigma$ and has a standard deviation of $\sigma$, what fraction of the probability of the distribution function is at zero or below? Equivalently and symmetrically, we could say, if the distribution is centered at zero, what is the fraction of the probability contained beyond $4.2\sigma$.
You can look those values up in probability tables that give the integral under a normal distribution between $-\infty$ and $z$, where in this case $z=4.2$. This is the probability of rejecting the hypothesis that the two measurements are the same and is 0.99998665.
EDIT: A.V.S makes the point (as did I), that the above analysis assumes the probability distributions of the measurements follow a normal distribution. In particular, if the wings of the probability distribution are bigger - e.g. a Student's t-distribution - then this means the "overlap" between the measurement probability distributions is larger and so the significance of a $4.2\sigma$ discrepancy is lower than a calculation based on the normal distribution.