Operators in Heisenberg picture are time-dependent while those in Schrödinger picture are time-independent, and they are related by $$A_H(t)=U^\dagger(t,t_0)A_S(t_0)U(t,t_0)$$ where $U(t,t_0)$ is the unitary evolution operator.
Does it mean it is not possible to work with the Schrödinger picture for time-dependent Hamiltonians? If yes, what does it even mean, in this case, to work in the Schrodinger picture because the operators are time-dependent?