By convention, the electric current positive direction is the direction in which positive charge moves. It is unclear in your schematic what the "rectangle on the right" represents: a voltage source, a resistor, or something else?
I would read the current in your schematic as follows:
- current magnitude is $2 \text{ A}$
- positive charge moves from right to left; hence, potential on the right is higher than potential on the left
If you are still confused by the negative sign, just flip the arrow of the current direction (rotate by 180$^\circ$) and put positive sign next to the current.
Can current also flow from low potential to high potential?
In the absence of external forces, positive charge always moves from higher to lower potential, much like objects fall from higher to lower altitude. However, charges can go from lower to higher potential if there was something providing the force necessary to overcome the potential difference; e.g. a voltage source (battery). This is the same as you climbing to a higher altitude by using an elevator.
It is also possible for positive charge to move from lower potential to higher potential by means of power converters. These use semiconductors (diodes and transistors), inductors and capacitors to transfer energy (power) from input to output. Physics still apply to power converters, but it is the way how they work that enables positive charge to flow from lower to higher potential.