In $2-2$ scattering, the Mandelstam variables $s$, $t$ and $u$ encode the energy, momentum, and angles of particles in a scattering process in a Lorentz-invariant fashion.
$$s=(p_{1}+p_{2})^{2}=(p_{3}+p_{4})^{2}$$ $$t=(p_{1}-p_{3})^{2}=(p_{2}-p_{4})^{2}$$ $$u=(p_{1}-p_{4})^{2}=(p_{2}-p_{3})^{2}$$
where $p_1$ and $p_2$ are the four-momenta of the incoming particles and $p_3$ and $p_4$ are the four-momenta of the outgoing particles.
How is $s$ is the square of the center-of-mass energy?
How is $t$ the square of the four-momentum transfer?
What is the physical interpretation of $u$?
Are $s$, $t$ and $u$ related to the $s$-channel, $t$-channel and $u$-channel respectively?