There is a massive debate raging about whether the wavefunction is an aspect of reality or just a way of handling the data you have about a system. This question is in that vein.
A local unitary on a qubit is an operator, $O$ on a two dimensional hilbert space, for which there exists an adjoint, $O^{\dagger}$, such that $O O^{\dagger} = I$.
Suppose you have an entagled pair of qubits. Next, suppose you perform a Uniformly random, local unitary, which you have no knowledge of, on one of the qubits. Does this destroy the entanglement?
I would say that the entanglement is destroyed if the value $E= Tr(\rho_a ln(\rho_a))$ departs from its original value, of say 1, towards 0. $\rho_a$ is the density matrix of the $a$ qubit.
Note: My first guess is that for states like this: $\psi = | 00 \rangle + |11\rangle$ the Von Neumann entropy, $E$ is 1. If you apply a random unitary to any one qubit, you are just randomizing an already completely random state, so there is no effect, so, no, you cannot destroy the entanglement with a random local unitary.