In a sense, the question is ambiguous because it doesn't tell you what to use as your $0$ of electric potential. But presumably your professor made it clear that in situations like these you are supposed to assume that the potential at infinity defines your zero of potential. With this in place, the question is asking what is the potential difference between infinity and the horizontal line?
The easiest way to see that the potential is zero everywhere on the line is by looking at a transformation that is a symmetry of the problem. The symmetry operation we will look at is inverting the four charges and reflecting them over the horizontal line.
This symmetry leaves the charge distribution the same and keeps infinity at infinity. Thus the potential difference between a point on the line and infinity must be the same after this transformation.
However, we also know that reflections have no effect on potential difference and inverting the charge distribution multiplies the potential difference by $-1$. Therefore the effect of the composition of the two things must be to multiply the potential difference by $-1$.
Thus if $V$ is the potential difference between infinity and a point on the line, and $V_f$ is the potential difference after the transformation, then, since the transformation is a symmetry operation, we must have $V=V_f$, but on the other hand, since the symmetry inverts the charges we must have $V_f=-V$. From this we conclude $V=0$.