In any living organism there exists are space between cells filled with interstitial fluid. Loss of this fluid into abnormal areas (3rd spacing) can cause relative to severe hypo-volemia. The fluid holds the cells in place and acts as a buffer.
Picture a bowl full of clear glass marbles. Fill it with clear liquid. Slowly drain the fluid out. The marbles cannot contort to fill in the gaps. If the system were closed and the water pumped out, a tremendous, Incompressible, vacuum would occur.
Living cells, on the other hand, CAN disfigure. Of course, this causes, depending upon the amount if distortion, cellular function disruption. In the case if someone losing interstitial fluid as a result if external trauma, the O2 sat levels will fall, leading to an initial decrease in the level of consciousness. Unabated loss will end in death.
What if the obvious space between molecules? Cells are, after all, just that. Living carbon-based masses of molecules. Remove the carbon, glucagon, and you have no life.
I submit that there must exist a 0 pressure 'dead-space' between molecules. Arguments?