Currently, the only ways to measure gravity is on quite large scale. So these experiments measure gravity averaged between vast systems of particles. Of course, such an averaging results¹⁾ in a spherically-symmetric field.
¹⁾ This neglects interaction between particles which may have had a chance to “align” them.
So how much (if any) the current measurements restrict the possibilities of asymmetry²⁾ on the level of individual particles?
²⁾ I never saw such a mechanism for antigravity “invented in SF”. If the asymmetry is so large that the interaction is repelling in some directions, then “suitably aligning³⁾ the particles of a car” could make it fly.
³⁾ Of course, this may require applying a lot of energy.
(Having small artificial satellites orbiting other planets allows to clock the solar system quite precisely. — However, the huge number of particles in Sun may make this approach useless. I cannot estimate quickly whether existing gravity experiments on the Earth orbit would be more productive.)
Update: one should distinguish two types of asymmetry. In general, the interaction may depend on “orientation” of two particles (relative to the line connecting the particles). Call this orientation as grin (for what follows it is not relevant whether this is a vector/direction/tensor/whatever). Note that we can take an average of the interaction over all possible grins of one particle.
In one possible case, this would make the interaction independent of the grin of the other particle. In the other case, a certain “residual asymmetry” still remains after such averaging.
Anyway, it seems that the first case should be much harder to refute than the second one…