I would argue that it can be very convenient to switch between the two perspectives and thus is actually exploited in physics literature precisely because the mathematics is easier to handle, rather than there being any "deep significance". But being mathematically convenient to handle is a big win and pretty significant in my book :-).
See this paper by Cotler et. al: https://arxiv.org/abs/1702.06142. One of the points of the paper is to start with an abstract Hilbert space $\mathcal{H}$ and Hamiltonian $\hat{H}$ and see if there is a unique, preferred tensor product factorization of $\mathcal{H}$ in which $\hat{H}$ is $k$-local. This criteria and the precise details of the paper are not important for this answer.
What is a tensor product factorization? Well, it is an isomorphism $T: \mathcal{H} \rightarrow \otimes_i\mathcal{H}_i$. So, we are sending our utterly abstract Hilbert space $\mathcal{H}$ into a tensor product factorization of said space. For example, a two spin-1/2 particle system is dimension 4. Thus, the only non-trivial tensor product factorization is $T: \mathcal{H} \rightarrow (\mathcal{H}_1 \cong \mathcal{C}^2) \otimes (\mathcal{H}_2 \cong \mathcal{C}^2)$.
Looks familiar? Well it should. This is basically how we represent choosing a basis for a vector space, i.e., by defining an isomorphism. Thus, changing the tensor product factorization of an abstract vector space can be thought of as a "change of basis" and will sometimes be referred as such. More intuitively, your choice of basis and choice of tensor product factorization both contribute to how your vectors are labelled.
Now, to answer the questions the paper asks, Cotler et. al is interested in looking at these mathematical structures determined by the 3-tuple $(\mathcal{H}, \hat{H}, \mathcal{T})$ where $\mathcal{T}$ is an equivalence class of tensor product factorizations $T$ that are equivalent on common sensical or physical grounds. They want to keep $\mathcal{H}$ and $\hat{H}$ fixed, vary $\mathcal{T}$ and check for each $\mathcal{T}$ if $\hat{H}$ is $k$-local.
Cotler et. al could if they really wanted to stick with this perspective to answer the question. However, it is really confusing to do so. What if we could instead keep $\mathcal{H}$ and $\mathcal{T}$ constant while varying $\hat{H}$? This is much simpler because we can actually fix a tensor product factorization and simply change the Hamiltonian (instead of changing between equivalence classes of isomorphisms)! Well, it turns out that these two perspectives are equivalent and very analogous to the active vs. passive transformation perspectives mentioned in your post.