In several different contexts, I've heard the claim that quantum gravity in an accelerating universe messes with our ability to define precise quantum observables.* One version of the argument goes roughly as follows; we need to perform a measurement infinitely many times to get a precise outcome. To prevent quantum fluctuations of the measurement apparatus from destroying the result before we're done averaging, we need our apparatus to be infinitely big. Therefore any measurement performed in a finite space is fundamentally indeterminate, and thus 'local observables' do not exist. Even more troublingly, we can't actually make our experimental apparatus infinitely big, since our accelerating universe has a cosmological horizon. So no measurement of any observable can give an arbitrarily precise result.
I gather that this argument or something like it has been known and worried about for decades, and is given as strong evidence that quantum mechanics is in tension with cosmology in De Sitter space. But at a philosophical level I can't see why it should imply something so profound. The inability of a finite measurement apparatus to average forever seems like a practical limitation, and not something a theorist should worry about so much.
So my questions are the following:
Why should the inability of an experiment to average infinitely long imply that the observed quantity is fundamentally ill-defined? There's even a way to give operational meaning to these observables, if you'll grant me multiple copies of the universe; a theorist outside the universe can still define and compute experimentally accessible observables to arbitrary precision, and this prediction can be compared against the combined outcomes of many experiments conducted in an ensemble of identical universes.
The above argument is a bit vague, and I suspect that it is an attempt to simplify a sharper, more mathematical statement. Is this so, and if so then what is the more precise statement of the issue at hand? Does it have a name, or a body of literature where can I read more? I gather it may be related to issue with defining the S matrix in cosmology, since you can't take the ingoing and outgoing states to infinity (though I'm not sure).
You can find this argument given by Nima Arkani-Hamed at the time linked within this video. And it's not like he thinks this is just some philosophical issue. He takes it as evidence that we need to understand how time emerges from something deeper, analogous to how space emerges in holography (i.e. AdS/CFT).
*Note that this argument goes way beyond the usual argument that you cannot probe distances smaller than the Planck length, since attempting to do so would create a black hole. This simpler thought experiment is taken to imply that there is no operational definition of length below the Planck length. It is a statement about the interpretation of a single measurement/observation, and unlike the above it really prevents even a theorist from saying anything of observable consequence about shorter distances.