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After replacing the derivative in the Klein-Gordon equation with the minimal coupling prescription i.e. $\partial^\mu \to D^\mu \equiv \partial^\mu+ieA^\mu$. The equation becomes: \begin{equation*} ((\partial_\mu +ieA_\mu)(\partial^\mu+ieA^\mu)+m^2)\phi(x)=0 \end{equation*} \begin{equation*} (\partial_\mu\partial^\mu +m^2 +ie(\partial_\mu A^\mu +A_\mu \partial ^\mu)-e^2A_\mu A^\mu)\phi(x)=0 \end{equation*}

In the book "Introduction to Particle and Astroparticle Physics" by Alessandro De Angelis, the book makes the following substitution in the above equation calling it potential: \begin{equation} V(x)=ie(\partial_\mu A^\mu +A_\mu \partial ^\mu) \end{equation} which gives us the final equation. (neglecting $e^2$ term which is of second order): \begin{equation*} (\partial_\mu\partial^\mu +m^2 +V(x))\phi(x)=0 \end{equation*} My question is what is the significance of V(x)? As in what is this potential? Further if we assume the lorenz guage i.e. $\partial_\mu A^\mu =0$, how does that change the description of this potential?

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Well, I don't have an explanation as I don't dispose of the mentioned book. Probably it is the best to continue to read to find out why this notation was chosen. But I would like to point a couple of details which might help.

One should understand $V(x)$ as a differential operator. Therefore one should better write:

$$V(x)\phi = ie (\partial_\mu (A^\mu \phi) + A_\mu \partial^\mu\phi)$$

which can be changed to:

$$V(x)\phi = ie (\phi \partial_\mu A^\mu + 2 A^\mu \partial_\mu \phi)\stackrel{Lorenz\, gauge}{=} 2ieA^\mu \partial_\mu \phi $$

I even see applications of this result. Let's assume that the potential is only electrostatic and constant: $A^\mu = (W,0,0,0)$. So we get the following Klein-Gordon equation:

$$(\Box +m^2)\phi = -2ie W\frac{\partial \phi}{\partial t}$$

So in this case $V(x)\phi = 2ie W \partial_t \phi$.

BTW this equation has a simple solutions if the particle described by the field is at rest (momentum is zero):

$$\phi_\pm \approx e^{i (\pm m -eW)t }$$

One can now think about what these 2 solutions mean, in particular because one of them is of negative energy (better assume $eW <<m$). But this goes far beyond the question.

So the main message here is that one has to consider $V(x)$ as differential operator and applications exist.

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