My understanding is that, to define the reference frame under use in a differential equation describing the motion of a particle, initial conditions are required; and in fact, it is the initial conditions $x(t_0)=x_0$ and $v(t_0)=v_0$ that define, uniquely, the coordinate system in use.
I understand why the condition $x(t_0)=x_0$ is necessary, but not why $v(t_0)=v_0$ also is. I'd be grateful if you would help me out with my understanding of what exactly defines uniquely the reference frame in a problem involving the motion of particles.