In General Relativity spacetime is a four-dimensional oriented and time oriented Lorentzian manifold $M$. Consider then one coordinate system $(U,x)$ on the open set $U\subset M$.
This determines the coordinate functions $x^\mu : U\to \mathbb{R}$ so that
$$x(\mathscr{A})=(x^0(\mathscr{A}),x^1(\mathscr{A}),x^2(\mathscr{A}),x^3(\mathscr{A})), \quad \forall \mathscr{A}\in U.$$
My question is: when we have a coordinate system, when does $x^0$ represents time and $x^i$ for $i=1,2,3$ represents spatial coordinates?
How can we know if a coordinate system is like this?
In the way I have learned, an observer is a timelike future pointing worldline $\gamma : I\subset \mathbb{R}\to M$ together with four vector fields along $\gamma$, $e_\mu : I\to TM$, with $e_0 = \gamma'$ and $g(e_\mu,e_\nu)=\eta_{\mu\nu}$. In that setting one defines the time interval between the events $\gamma(0)$ and $\gamma(1)$ to be:
$$\tau=\int_0^1 \sqrt{g_{\gamma(\lambda)}(\gamma'(\lambda),\gamma'(\lambda))}d\lambda$$
In the way I've been learning GR this is the only situation in which time appeared. No more has been said about time, nor space, separately.
So my question is: given a chart, and given this notion of observer and of time interval, when does $x^0$ represents time and when $x^i$ represents space?