What you're looking for (I assume, based on your example) is a quantum operation which takes
$$ (\alpha, \beta, \gamma, \delta)$$
to
$$ (\alpha, u, \gamma, 0)$$ with probability $\frac{|\beta^2|}{|
\beta^2| + |\delta^2|}$
and
$$ (\alpha, 0, \gamma, u')$$
with probability $\frac{|\delta^2|}{|\beta^2| + |\delta^2|}.$
If you insist on getting the result of the measurement somehow, then this is impossible, because if you start with a few copies of a state $$(\alpha, \epsilon_1, \gamma, \epsilon_2),$$ then assuming you can do what you want, you will be able to approximate the ratio between $\epsilon_1$ and $\epsilon_2$ regardless of how small $\epsilon_1$ and $\epsilon_2$ are, something which violates the principles of quantum mechanics.
ANSWER TO REVISED QUESTION:
You want to start with $(\alpha, \beta, \gamma, \delta)$, and get $$(\alpha, e^{i\theta}\sqrt{|\beta^2|+|\delta^2|}, \gamma, 0).$$
This is impossible. Suppose first that the phase is always 1. This means that you can start with $(\frac{\alpha}{2}, \pm\frac{\beta}{\sqrt{2}}, \frac{\alpha}{2},0)$, and get $(\frac{\alpha}{2}, \frac{\beta}{\sqrt{2}}, \frac{\alpha}{2},0)$. However, if you started with a mixture of the two vectors $(\alpha\frac{1}{2}, \pm\beta\frac{1}{\sqrt{2}}, \alpha\frac{1}{2},0)$, this is the same as a mixture of the vectors $(\frac{1}{\sqrt{2}}, 0,\frac{1}{\sqrt{2}},0)$ and $(0,1,0,0)$. Your operation takes a mixture of these two vectors and turns it into a superposition of these two vectors. But turning a mixture into a superposition is impossible by the laws of quantum mechanics.
This means that the operation must preserve phases. But now, we somehow need a quantum operation that maps points on the Bloch sphere composed by the second and fourth coordinates of your vector into a single dimension. This is the same as putting a complex phase on each point of the unit sphere so that opposite points have the opposite phase. That is, you want a continuous map of the unit sphere onto the circle with antipodes mapped to antipodes. I am fairly sure this is topologically impossible (although I'd appreciate anybody who can cite a theorem proving this).