Suppose the universe is completely empty with one sole particle trapped in it. To simplify, I will only be looking at the one dimensional case. However, all arguments are applicable for three dimensions. The solution of the Schrödinger equation $\hat{H} \psi = E \psi $ with $\hat{H} = \frac{\hat{p}^2}{2m}$ and $\quad \hat{p} = -i\hbar \frac{\mathrm d}{\mathrm d x}$ for a free particle ($V=0$) is then given by $\psi(x,t)=A\exp{i(kx-wt)}$ with constants $w=\frac{E}{\hbar}$ and $E=\frac{\hbar^2k^2}{2m}$ which can easily be shown. In order to meet the criteria of QM, $\langle \psi|\psi\rangle$ needs to be normalized (=1). If that is not possible, there is no way such a quantity can be interpreted as a probability density. However, if you try to normalize the density you will find:
\begin{align*} \langle\psi|\psi\rangle &=\int_{-\infty}^{\infty} \psi \psi^* dx \\ &= |A|^2 \int_{-\infty}^{\infty}\exp{i(kx-wt)} \exp{-i(kx-wt)}\mathrm dx \\ &=|A|^2 \int_{-\infty}^{\infty}1\cdot\mathrm dx\\ &=\infty\,. \end{align*}
Thus, it is not possible to find said normalization. Asking around, I found that such cases are normally treated as an approximation of a very wide (yet finite) potential well, or in the 3-dimensional case, a box. This allows a fairly simple solution which can be normalized. However it only represents an approximation. In a rigorous point of view there exist no such solutions which satisfy the postulates of Quantum Mechanics. Does that mean that the laws of QM fundamentally prohibit a infinite empty universe with only one sole particle trapped in it?