If we can control physics to our liking, there may be a few other possibilities, but we still seem privileged.
Lets look at these parameters:
- Number of space dimensions.
- Number of time dimensions.
- Dimension of the worldlines.
And here is the best guesses for different spacetimes:
3+1, 1D world lines. We are here, with 1D worldlines tracing out curves in 3+1 spacetime.
1+3. We are also here. There is no way to differentiate between $m+n$ and $n+m$.
4+0 and 2+2, 1D world lines. These allow closed timelike curves. Causality feels very important in terms of avoiding all sorts of strange paradoxes, so it seems hard for sentient life to exist in a universe that doesn't enforce causality. Both of these also have issues with stability since it is possible to generate an arbitrary amount of mass or energy from nothing. Nevertheless, Greg Egan has explored both of these in his novels.
1+1, 2+1. Planets don't have gravity in 1+1 or 2+1, but 2+1 can still have a big bang with cosmic inflation. Perhaps life floats freely in space filled with gas and dust? How would two neuron axons cross without mixing up the signals? Conways life can do so with timing, i.e. using "stoplights" at intersections. However, having evolution do so at the scale of intelligent life could be insurmountable; 2D space has low fertility so to speak.
4+1 (and 5+1, etc). In 3+1 forces would follow inverse cube law. This makes orbits unstable. Electron orbitals also are unstable; this is called the falling to center problem. But with extensive tweaking of forces and elementary particle masses it is possible to mix attractive and repulsive Yukawah potentials at various scales to allow stable atoms forming solids and liquids on a stable planet/star. So stability is not insurmountable like the 4+0 case, but achieving it sacrifices parsimony.
3.5+1: Are fractal dimensions possible? This has been explored for quantum field theory. For 3.5 spatial dimensions you would have inverse 2.5 law instead of inverse square law. Orbitals would be stable (they are stable for anything below inverse cube). The surface of planets would be 2.5 dimensional: with $n$ buildings within 1 km you could expect $4\sqrt{2} n = 5.66n$ within 2 km. There is no need to cross streets for d=2.5. This is all wonderful, except that non-integer dimensions would (I think) make space itself fractal: there would be "bubbles" of "non-space" at all length scales. This would prevent momentum from existing: any travelling wave immediately "hits" these bubbles and scatters in all directions. You couldn't throw a ball, shine a laser or see distant objects, get caught in a cyclone, or even have sound. Light diffuses instead of propigates, illuminating both the "day" and "night" side of your planet almost equally. Away from the bubbles are regions (on all scales) where space is "denser". City-scale "dense zones" are prime real-estate since you can fit more buildings within a 1km distance. Planets would be "glued" to large dense zones where more mass can be compressed into less "distance". Put your brain in a head-sized dense zones and your neurons pack more tightly; in general anything that moved would have to keep reconfiguring itself as the space it was in changed. The lack of momentum is bad for fertility and the difficulty of incorporating general relativity raises issues of parsimony.
3&4+1: One could have a semi-compact dimension along with 3 non-compact dimensions. Suppose the extra dimension was 1000km long. Particles moving in the 4th dimension would "wrap around" and return to the origin after travelling 1000km. Forces such as gravity are inverse-square for inter-planetary scales and higher but transition to inverse-cube at shorter distances. Matter would need a Yukawah-like stabilization. Keeping the extra dimension at an "interesting" scale takes a huge parsimony cost.
3+2, 2D worldlines: Instead of worldlines, what about world planes? There would be 3 spatial dimensions left over for 3+2. This exotic-sounding situation may not actually be distinguishable from our own universe. Consider a classical, Newtonian test particle in a gravity well. At a point in time there would be two 3D velocity vectors: $v_{1}(t_a,t_b) = dx/dt_1, v_{2}(t_a, t_b) = dx/dt_2$. You also have gravitational forces: $\ddot v_1, \ddot v_2$. Neither the two forces nor the two velocities need be the same. However, you can choose a time direction: $t=\alpha t_1+\beta t_2$ and then evolve the dynamics of the system along that time direction. Doing so would be no different than having a single time direction. Timepoints outside of the timeline are in parallel universes and what happens there does not affect the timeline itself. I am 99% sure this argument would generalize to relativity and quantum field theory and we will get 3+2(2D) = 4+1(1D).
In summary: There are several fundamental "privileges". Causality allows "people" to have a "history" that is safe from paradoxes. Stability prevents the highest entropy state from being reached instantly. Life then steps in and moves things toward equilibrium, extracting energy in the process. Complex life is much easier if the physics have good fertility. Parsimony reduces the need for fine tuning, which means that it is more likely a "random" set of dimensionless physical constants allows life to exist. If we desire all these "privileges", (what is indistinguishable from) 3+1 is the winner. However, parsimony is not as necessary as the other criteria so 4+1, 5+1, etc are not ruled out either.
:-)
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