From Beyond Einstein, by Michio Kaku and Jennifer Thompson, Chapter 13, Antimatter :
Dirac, also focused on the fact that Einstein's equation $E=mc^2$ wasn't totally true. (Einstein was aware that the true equation was $E=\pm mc^2$ but as his theory was based on forces, he ignored the minus sign.) As Dirac was creating a new kind of equation (known as Dirac's equation) for the electron, he shouldn't ignore the minus sign. This sign was intriguing people, because this, seems like he predicted a whole new type of matter.
So if I understand correctly, matter (as always known) follow the equation $E=mc^2$ whereas anti-matter follows the equation $E=-mc^2$. But a few paragraph later, it says :
When matter and anti-matter collide, they annihilate each other and an enormous amount of energy comes out.
When I thought a little bit, if a particle carrying $mc^2$ amount of energy, and it's anti-patricle carrying $-mc^2$ amount of energy then the total energy carried by both particles should be $E_{total}=E_{particle}+E_{anti-particle}=mc^2-mc^2=0$. I think that everyone can see here the problem : there are not any energy in total with both particles. So where this huge energy comes from when the particle and anti-particle collide? Or is it me misinterpreting what I've read?