In general one first writes the term out completely, $$\partial_u (x^2 ~x_v) = \partial_u (\eta_{mn}~\eta_{vt}~x^m~x^n~x^t),$$ then one expands out with the product rule, $$
\begin{align}
\partial_u (x^2 ~x_v) =~& (\partial_u \eta_{mn})~\eta_{vt}~x^m~x^n~x^t
+ \eta_{mn}~(\partial_u \eta_{vt})~x^m~x^n~x^t + ~\\
& \eta_{mn}~\eta_{vt}~(\partial_u x^m)~x^n~x^t + \eta_{mn}~\eta_{vt}~x^m~(\partial_u x^n)~x^t +\eta_{mn}~\eta_{vt}~x^m~x^n~(\partial_u x^t).
\end{align}$$Note that in special relativity the first two terms are zero because the metric tensor $\eta$ is constant over spacetime. (In general relativity $\eta$ becomes $g$ and $\partial$ becomes $\nabla$ and these terms still vanish, but that's only true because we choose a specific connection which makes them vanish.)
Aside from $\partial_{\bullet} \eta_{\bullet\bullet} = 0$ we also can simplify the last three terms because we have that $\partial_a x^b = \delta_a^b,$ the Kronecker delta. This forces in the first of the three an identification $u=m$, so one gets $x_u x_v$ for the first term, for example.
Note that your gut intuition, which is that $\partial_u$ is selecting out what to act upon by its index, is wholly incorrect here and needs to be abandoned. $\partial_\bullet$ is a spacetime gradient, full-stop. It applies to all three $x$ terms which all refer to the spacetime position. It happens to have a lower index, because spatial gradients always produce covectors, and the lower index identifies that this is a covector field, not a scalar field.