One serious challenge in transitioning from "normal" quantum mechanics to relativistic quantum mechanics is that time and space have to be on the same footing. In nonrelativistic quantum mechanics, position is treated as an operator, while time is just a label on the wavefunction. One way to get around this problem is to demote position so that it is no longer an operator and merely plays the role of a label on the wavefunction.
Of course, that raises the question of which Hilbert space does the wavefunction occupy, since there is now no such thing as a position basis. The answer comes from quantum field theory. In quantum field theory, we abandon the concept of individual, isolated particles (after all, $E=mc^2$ implies new particles can be created out of energy). Instead, we treat fields as the fundamental objects and quantize them. What we end up with is an infinite number of degrees of freedom: one for each point in spacetime (the field can take any value at each point in spacetime). In "classical" quantum mechanics, there are three infinite degrees of freedom (for example, one for each spacial direction). In quantum field theory there are an infinite number of infinite degrees of freedom. The wavefunctions may be expanded in various bases belonging to infinite families of operators.