Simply put, Newton's 3rd Law is an observation that (at least in classical physics) has proved to be true through experiment. Several other equations and relations exist which are axiomatic (such as Schrodinger's equation) and are obtained simply through observation.
Intuitively, consider a universe which only contains a ball. Can the ball accelerate if it has nothing to push off of? If so, what is it moving relative to? A ball in its own universe can only move relative to itself - its velocity is zero; it has no acceleration.
Furthermore, consider a universe with a ball and a person. The person throws the ball, imparting an impulse which gives the ball velocity and momentum. The average speed of the universe relative to itself must be zero, so net momentum must be zero. To preserve a total momentum of zero, the person must receive an opposite momentum. This momentum is equal to mass times velocity. Force, mass times acceleration, is the time derivative of momentum. In order for the momenta to always be equal in magnitude and opposite in direction, the derivatives of the momentum should also be equal and opposite, ergo, Newton's 3rd law.