In Cuffaro and Hartmann's (2021) Open Systems View, the authors suggest, "The problem is that if the physical universe is not represented as a unitarily evolving state vector, then it becomes difficult to conceive of it in terms of a multiverse of effectively independently evolving worlds."
Why is this the case? Can we not get branching if the universe is in a mixed state, and evolves non-unitarily evolving mixed state represented by a density operator?
For those sceptical of non-unitary evolution in EQM, both Wallace (Emergent Multiverse 2012 §10.5) and Carroll (Reality as a Vector in Hilbert Space 2021) consider this to be a possibility.