As I've stated in a prior question of mine, I am a mathematician with very little knowledge of Physics, and I ask here things I'm curious about/things that will help me learn.
This falls into the category of things I'm curious about. Have people considered whether spacetime is simply connectedsimply connected? Similarly, one can ask if it contractible, what its Betti numbers are, its Euler characteristic and so forth. What would be the physical significance of it being non-simply-connected?