This problem has arisen in my research and reduces to the following.
Alice tells Bob she has secretly picked A or B. Depending on which she has picked she will send him states from a set. Bob can ask for as many states as he likes, but Alice will send a random member from the set, not the same state many times.
Set A consists of simple product states such as |0010> and |1100>
Set B consists of simple equal superpositions of two of the above states such as:
$$ \frac{1}{\sqrt{2}} (|0001>+|0101>) $$
Is it possible for Bob to determine which selection Alice has made?
Things I note/have tried:
For larger numbers of qubits, states from set B are almost certainly entangled. This doesn't necessarily make it possible to distinguish them from unentangled states in A.
One way to confirm that they cannot be distinguished would be to show that their density operators are equal. In a similar problem where Alice sends 2-qubit product states OR Bell basis states, it is easy to prove the density operators are the same and the states cannot be distinguished. I have tried this approach but found it sensitive to the probability distribution over the set.