This question mainly arises from thoughts concerning the quantum system of a single particle in the real half-line.
As it is known from the literature, a careful analysis of the position and momentum operator for this system in the position representation, where the operator $\hat{x}$ acts as a multiplicative operator and the operator $\hat{p}$ acts as a differential operator, each in a proper domain, leads to conclude that the momentum operator $\hat{p}$ is not essentially self-adjoint and it does not admit any self-adjoint extensions. In other words, the momentum, defined as above, cannot be an observable for the system.
(I summarized this part very briefly, assuming all the details are known, but to be clear the analysis I am referring to is analogue to the one discussed here: What's the deal with momentum in the infinite square well?)
This also should suggest that the p-representation is not a physical representation and hence it is not viable.
Nevertheless, if I start again from scratch, assuming that the only content of my knowledge is the algebra $[\hat{x},\hat{p}]=i\hbar$ and the configuration space represented from the positive real half-line, in principle I could make use of the p-representation. But in this representation, where the operator $\hat{p}$ acts just as a multiplicative operator in a proper domain, I cannot see how I can obtain the same conclusion about its self-adjointness. And if this is true, that is that in this representation p can be self-adjoint, how it is possible to conciliate this result with the former one about the observability of momentum?
I can see that I am handling two different operators in different spaces and from this perspective, it could be reasonable to obtain that one does not admit self-adjoint extensions while the other does. But from a physical point of view concerning the status of observable of a theory I am lost.
So, there should be a loophole somewhere for sure, but I am not able to find it.
Thanks all in advance.