Different people use the word "frame" in a great variety of ways. The answer to this (and to your other questions about frames) depends on what you mean by the word "frame". Since you haven't told us that, there's no way to answer your question.
At every event in spacetime, there is a tangent space. A basis for that tangent space is called a frame. (You can think of the elements of that frame as pointing in the directions that you plan to call "left", "forward", "up" and "future".)
You can exponentiate a frame to get a coordinate system on all of spacetime (or in the case of general relativity, on a part of spacetime). (Exponentiating essentially means replacing your tangent vectors with curves that travel as closely as possible in the directions that the tangent vectors point. Those curves then serve as ``axes'' for your coordinate system.) People often call that coordinate system a "frame", which is arguably an abuse of language but a common and harmless one (harmless because everyone understands what's really meant). If you like, you can envision this coordinate system as being made out of "clocks and rods", though personally I think this adds nothing and sometimes causes confusion.)
Often it is implicitly assumed that frames are orthogonal (also called "intertial"), and then the associated coordinate system is often called an "inertial frame" (though it's still not literally a frame at all).
Or you can start with a non-orthogonal frame, and you can exponentiate that to get a non-orthogonal coordinate system.
Or you can associate a different frame to every point in spacetime, in a continuous way. The right word for this is "section of the frame bundle", but again, people frequently just say "frame". Or you can do this just for the events that lie along some specific curve, etc.
Or you can construct a coordinate system that is not the exponential of any frame at all, though your coordinate system now determines a section of the frame bundle.
Sometimes people speak of "accelerated frames". It seems to me that different people use this word in many ways --- to mean a literal frame that is not orthogonal, or to mean a section of the frame bundle that is not constructed by parallel transport, or to mean a coordinate system that is not the exponential of any frame.
To make any sense of your questions, you need to decide what you mean. After you have some experience, you can decide for yourself which abuses of language you are comfortable with. Until then, I recommend sticking with a careful, precise definition: A frame is a set of four vectors. Sometimes one identifies that frame with its own exponential (which is now a coordinate system). It's probably best to require your frames to be orthogonal. Any talk of "accelerated frames" or "the frame of an accelerating rocket" is fraught with ambiguity and really ill-advised right now.