Consider the Dyson series of the $S$-matrix of Quantum Electrodynamics. The second term in this series predicts non-zero probability amplitudes of observing photons that are off-shell.
For an incoming state of a positron and an electron, the second term of the series gives a non-zero amplitude that the final product is an off-shell photon.
So why don't we observe these photons? Is it simply because Einstein's energy relation forbids their existence? But then that means the probability of observing them is 0, which contradicts the non-zero probability predicted by theory. If you simply set it to zero in an ad-hoc manner, then the other probabilities wouldn't add to 1.
Edit I mean the operator $$A_{\mu}^-(x) \psi^ {'+} (x)\gamma ^{\mu} \psi^+ (x) $$
$\psi ^{'}$ means the spinor adjoint. This term is part of the Dyson series. It's been normal ordered using Wick's theorem. This creates off-shell photons when operated on $|e^+e^-\rangle$, and just leaves them there! The off-shell photons are the final products of this operator.