In the usual example of the Casimir effect we have two metal plates seperated by some small distance and a quantum field that lives both outside and inside of these plates. The boundary condition for the field inside constraints the allowed modes and thus alters the energy expectation value. The energy both inside and outside is of course infinite but by means of regularization we can assign a negative energy density to the inside, where this quantity makes sense in comparison to the vacuum without the plates.
I wonder now what happens if we don't allow for a quantum field to live outside? So considering an alternate spacetime where one spatial coordinate has a finite (small) range. By imposing vanishing boundary conditions we obtain a similar problem as above. Will there be Casimir force in that scenario? And how could a negative energy make sense, when there is no "unperturbed vacuum" in that case to compare to?