Theoretically, could radio waves carry enough energy to destroy bacteria or viruses by resonance? I've been reading recently about a mysterious and possibly hokey medical device of the 1930s.  It was a variable-frequency radio emitter, invented by a Dr. Rife, which was supposed to kill various types of bacteria and viruses by emitting the resonant frequency of that particular species, like a wine glass being broken by the right musical note.
(N.B. This gadget is not to be confused with various so-called "Rife machines" currently being sold in New Age circles, many of which seem to have been built by people with a shaky grasp of physics and bear very little resemblance to the original ones.)
A paper by the American Cancer Society, mentioning Rife's research, states:

(Note: Although sound waves can produce vibrations that will break glass, radio waves cannot destroy bacteria due to their low energy level.)

That's all it said about that, it was mostly concentrating on the even less credible modern rip-offs and their claims to be able to cure cancer.
This is intriguing.  I don't know enough about radio wave physics to answer this question, so I thought I'd put it to you.  Theoretically, could radio waves of the right resonant frequency have enough energy to destroy a bacterium?  What about a virus, which is usually much smaller?
If it's relevant, the output of the devices was from 50 watts to 500 watts depending on the model, and the power consumption was from 400 watts to 1,000 watts.
The frequencies used ranged from 100,000 to 1,700,000 Hertz.
Some examples of the infections it was alleged to be able to destroy included tuberculosis, tetanus, anthrax, gonorrhoea and typhoid.
The frequencies were determined empirically, according to Dr. Rife, by observing a microbial culture under a powerful microscope and going slowly through a range of frequencies until something happened, rather than by any theoretical calculation, so exactly what part of the microbe "resonated" and how (if indeed it did) is unknown.
 A: Viruses and bacteria, or in general pathogens, are very complex biological organisms with many large molecules with a wide range of structure, each of which will have their own resonant frequencies. Such a device would therefore need to produce an appropriate range of such frequencies to damage each of these molecules.
Is it possible? If you new what all these resonant frequencies are, then in principle such a device could be made. But I'm guessing some of these frequencies may correspond to resonant frequencies of nearby biomolecules and/or tissue thus having more of a destructive, rather than therapeutic affect.
But it will also be a challenge determining what all these  frequencies would be to begin with. The mechanism by which electromagnetic frequency emissions affect microorganisms is not fully understood, and there is a lot of ongoing research in this area.
Having said this, it may be sufficient to destroy part of the pathogen rather than all of it. This will require perhaps a handful of resonant frequencies that will destroy part of the pathogen disabling it, rather than killing it outright.
But again, this is unlikely to be successful (with current technology) due to the complexity of microorganisms, the risk to healthy tissue and the fact that the interaction of electromagnetic radiation with microorganisms is not well understood.
A: Royal Rife's approaches have not been recognized as an effective medical treatment by the scientific community - rather they are considered as complimentary and alternative therapy. In other words, it is an electromagnetic equivalent of hydroxycholriquine when used against COVID-19. So I think the question is not really suitable for this forum, as it falls beyond mainstream science.
However, just as with hydroxycholroquine, there are some high profile figures working on electromagnetic interactions in DNA and viruses, notably Luc Montagnier, the Nobel prize winner for the HIV discovery: see here. Needless to say that his DNA teleportation theory is highly controversial.
A: Let me try to answer this question of the perspective of what we actually can do and what the problems would be to translate it to something like the method in question.
Destroying the entire cell
Sonication is a method to destroy cell walls using ultrasound waves (20 kHz to 50 kHz) in vitro. If we could apply the same effect to pathogenic microbes inside a human, that would be indeed helpful. However:

*

*The wavelength of those sound waves is at about 7 cm, i.e., much larger than a microbe. It’s not a resonance phenomenon.


*Bacteria of a given strain have no single resonance frequency because they grow by a factor of two during their life cycle. Anything that catches all of this will almost certainly also destroy human cells or their components. This is somewhat better for virions which always have the same size, but then those are only part of the life cycle of a virus.


*Sonication generates a lot of heat. To mitigate this, samples are usually put on ice when sonicated, but you cannot do that with a human.


*Sonication uses, well, sound. While electromagnetically induced acoustic noise is a thing, it uses the conductivity or ferromagnetic properties of a material. Moreover, any mechanical oscillation is sound, so you would get all the problems of sound mentioned above – even if you managed to take a detour via electromagnetism to cause it.
Destroying specific molecules
Photobleaching destroys specific molecules with electromagnetic waves. You might call this resonance, but it’s certainly not comparable to a catastrophic resonance destroying a wine glass. Rather it’s a single photon with the right energy to excite the molecule and the molecule having a certain chance to be destroyed in the excited state rather than to de-excite. Either way, here are the problems:

*

*While the photons in question have a specific effect on certain molecules, they are still scattered by matter and do not permeate the body. You need to go to entirely different wavelengths to avoid this.


*Molecules that are receptive to an exclusive frequency are rare. Sure, every bond is a bit different because it depends on the entire molecule, but if two bonds are sufficiently similar, frequency broadening effects make selective destruction impossible.
A: In order for electromagnetic waves to  effectively destroy the structure of matter, i.e the bonds binding the molecules of the microbes etc to be destroyed, one should look at the energies. In quantum mechanics absorption and iozization happens when the appropriate energy is supplied, and destruction must have higher than that energy.
Found this for numbers:

Bond energies generally vary from about 10 electron volts (eV) to about 0.03 eV. Covalent bonds, where electrons are shared between atoms, tend to be more energetic than hydrogen bonds, where a hydrogen atom is shared between atoms, and hydrogen bonds in turn are more energetic than van der Waals forces, which arise from the attraction of the electrons of one atom for the nucleus of another. Atoms, free or bound, move with an average kinetic energy corresponding to about 0.02 eV. The higher the temperature, the more atoms move with energy sufficient to break a given bond spontaneously.

(italics mine, see below)
Look at the electromagnetic spectrum
Radio waves are of nano electron volt energy per photon, which is orders of magnitude smaller than the 0.02 electron volt needed to break a bond between the molecules that make the bacteria.
Microwaves in the ovens work in the bulk of matter,

This induces polar molecules in the food to rotate and produce thermal energy in a process known as dielectric heating.

even though also of too small an energy per photon can induce a thermodynamic enviroment of high temperature that can kill bacteria etc., and this is the closest one can come in using low energy electromagnetic radiation to destroy microscopic life.
Any resonance, should increase the heat of the medium in which the microbe lives, so the atoms could  acquire high enough kinetic energy
to be able to destroy the bonds holding the microbe together. This cannot be done with radio wave frequencies.
A: With all due respect to those who believe it is not possible to destroy germs with the use of resonant frequencies please watch the video here, https://www.youtube.com/watch?v=ZJQLs6kne3k
You are debating whether or not something is possible that has been shown to very real many times over
This video is one of more than a few showing the same effect and these video's been around for years
Please watch the TED talk given by Dr Anthony Holland and his work with cancer cells and resonant radio frequencies before proclaiming what is and is not possible
The device used for this video and Dr Hollands work was a 27Mhz transmitter with a modulation frequency range of about 500 hz to 10khz This effect has nothing to do with RF heating
