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\newcommand{\tl}[1]{\tag{#1}\label{#1}}
\newcommand{\hebl}{\bl{=\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!==\!=\!=\!=}}$
As concerns to isospin we consider the up and down quarks $\;\bl u, \bl d\;$ as two states of a single particle, the quark $\;q\in\mathsf Q$, and so the anti-up and anti-down quarks $\;\ol{\bl u\Vp{\bl d}},\ol{\bl d} ,\;$ as two states of the antiquark $\;\ol q\in\ol{\mathsf Q}$. To examine the transformation of combinations $\;q\ol q$ ($\bl\equiv\:\texttt{mesons}$) under $\mr{SU}\plr{2}$ we apply a special unitary transformation $\,^2U_{\bl q}\in \mr{SU}\plr{2}\;$ on the Hilbert space $\;\mathsf Q\;$ of quarks which necessarily implies application of its complex conjugate $\;^2\ol U_{\bl q}\;$ on the Hilbert space $\;\ol{\mathsf Q}\;$ of antiquarks. But we must apply on the Hilbert space $\;\ol{\mathsf Q}\;$ an identical special unitary transformation $\,^2U_{\ol{\bl q}}\bl\equiv{^2U} \bl\equiv {^2U_{\bl q}}\;$ since, as in the spin$\m1/2$ case, we want the isospin 3-vector $\;\mb I^{\ol{\bl q}}\e\plr{\mr I^{\ol q}_1,\mr I^{\ol q}_2,\mr I^{\ol q}_3}\;$ of the antiquark to transform (rotate) in exactly the same way as the isospin 3-vector $\;\mb I^{\bl q}\e\plr{\mr I^{q}_1,\mr I^{q}_2,\mr I^{q}_3}\;$ of quark $\;q$. And this demand is due to the fact that these two isospin 3-vectors live in the same artificial 3-dimensional space $\;\mathbb R^3\;$ and so we must not rotate the former 3-vector differently from the latter. This incompatibility is resolved by a proper change of the basis $\;\bl\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\bl\rbrace\;$ of the antiquark Hilbert space $\;\ol{\mathsf Q}\;$ as we'll see in the following.
So, consider a pair of quark-antiquark $\;\bl\xi,\ol{\bl\zeta} \;$
\begin{align}
\bl\xi&\e\xi_1\bl u\p \xi_2\bl d
\tl{01a}\\
\bl\zeta&\e\zeta_1\bl u\p \zeta_2\bl d\quad\bl\implies\quad\ol{\bl\zeta}\e\ol{\zeta_1}\,\ol{\bl u\Vp{\bl d}}\p \ol{\zeta_2}\,\ol{\bl d}
\tl{01b}
\end{align}
Their representation by matrices is
\begin{align}
\bl\xi&\e\underbrace{
\begin{bmatrix}
\xi_1 \vp\\
\xi_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}
\tl{02a}\\
\bl\zeta&\e\underbrace{
\begin{bmatrix}
\zeta_1 \vp\\
\zeta_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}\quad\bl\implies\quad
\ol{\bl\zeta}\e\underbrace{
\begin{bmatrix}
\ol{\zeta_1} \vp\\
\ol{\zeta_2} \vp
\end{bmatrix}}_{{\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\rbrace}}
\tl{02b}
\end{align}
A matrix standing alone has no sense. If so, it is implied that it represents something (vector, linear operator etc) with respect to some basis of a linear space. For our case here it's important to know with respect to which basis a matrix represents a vector or a transformation. That's why we declare the basis in underbraces.
Consider now that we apply a special unitary transformation $\;U \bl\in\mr{SU}\plr{2}\;$
\begin{align}
\bl\xi'&\e U\bl\xi
\tl{03a}\\
\bl\zeta'&\e U\bl\zeta\quad\bl\implies\quad\ol{\bl\zeta'}\e\ol{U \Vp {\zeta'}}\,\ol{\bl\zeta\Vp '}
\tl{03b}
\end{align}
with
\begin{equation}
U\e\underbrace{
\begin{bmatrix}
\hp\m g&\:\;h\:\:\vp\\
\m\ol{h}&\:\:\ol{g\Vp h}\:\:\vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}\,, \quad\texttt{where}\quad g\ol{g\Vp h}\p h\ol{h}\e 1
\tl{04}
\end{equation}
The matrix representation of equations \eqref{03a},\eqref{03b} gives
\begin{align}
\underbrace{
\begin{bmatrix}
\xi'_1 \vp\\
\xi'_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}&\e
\underbrace{
\begin{bmatrix}
\hp\m g&\:\;h\:\:\vp\\
\m\ol{h}&\:\:\ol{g\Vp h}\:\:\vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}
\underbrace{
\begin{bmatrix}
\xi_1 \vp\\
\xi_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}
\tl{05a}\\
\underbrace{
\begin{bmatrix}
\zeta'_1 \vp\\
\zeta'_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}&\e
\underbrace{
\begin{bmatrix}
\hp\m g&\:\;h\:\:\vp\\
\m\ol{h}&\:\:\ol{g\Vp h}\:\:\vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}
\underbrace{
\begin{bmatrix}
\zeta_1 \vp\\
\zeta_2 \vp
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}\quad\bl\implies\quad
\underbrace{
\begin{bmatrix}
\ol{\zeta'_1} \vp\\
\ol{\zeta'_2} \vp
\end{bmatrix}}_{{\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\rbrace}}\e
\underbrace{
\begin{bmatrix}
\hp\m \ol{g\Vp h}&\:\:\ol{h}\:\:\vp\\
\m h&\:\:g\:\:\vp
\end{bmatrix}}_{{\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\rbrace}}
\underbrace{
\begin{bmatrix}
\ol{\zeta_1} \vp\\
\ol{\zeta_2} \vp
\end{bmatrix}}_{{\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\rbrace}}
\tl{05b}
\end{align}
The complication is clear in above equations : while on the quark we apply the special unitary transformation $\;U$, on the antiquark we apply the special unitary transformation $\ol{U \Vp {\zeta'}}\bl\ne U\;$.
We override this complication expressing the relation to the right of equation \eqref{05b} as follows
\begin{equation}
\left.
\begin{cases}
\ol{\zeta'_1}\e\hp\m\ol{g\Vp h}\,\ol{\zeta_1}\p\ol{h}\,\ol{\zeta_2} \\
\ol{\zeta'_2}\e\m h\,\ol{\zeta_1}\p g\,\ol{\zeta_2}
\end{cases}\right\}\quad\bl\implies\quad
\left.
\begin{cases}
\ol{\plr{\m\zeta'_2}}\e \hp\m g\,\ol{\plr{\m\zeta_2}}\p h\,\ol{\zeta_1} \\
\:\:\:\:\,\ol{\zeta'_1}\:\:\:\e\m\ol{h}\,\ol{\plr{\m\zeta_2}}\p\ol{g\Vp h}\,\ol{\zeta_1} \\
\end{cases}\right\}
\tl{06}
\end{equation}
so
\begin{equation}
\underbrace{
\begin{bmatrix}
\ol{\plr{\m\zeta'_2}} \vp\\
\ol{\zeta'_1}\vp
\end{bmatrix}}_{{\lbrace \bl\m\ol{\bl d},\ol{\bl u\Vp{\bl d}}\rbrace}}\e
\underbrace{
\begin{bmatrix}
\hp\m g&\:\;h\:\:\vp\\
\m\ol{h}&\:\:\ol{g\Vp h}\:\:\vp
\end{bmatrix}}_{{\lbrace \bl\m\ol{\bl d},\ol{\bl u\Vp{\bl d}}\rbrace}}
\underbrace{
\begin{bmatrix}
\ol{\plr{\m\zeta_2}} \vp\\
\ol{\zeta_1} \vp
\end{bmatrix}}_{{\lbrace \bl\m\ol{\bl d},\ol{\bl u\Vp{\bl d}}\rbrace}}
\tl{07}
\end{equation}
We conclude that if in the space $\;\ol{\mathsf Q}\;$ of the antiquarks we use as up eigenstate of the isospin component $\;\mr I^{\ol q}_3\;$ the state $\;\plr{\bl\m\ol{\bl d}}\;$ instead of $\;\ol{\bl d}\;$ while keeping $\;\ol{\bl u\Vp{\bl d}}\;$ as the downstate then the transformation applied on the antiquark is identical to that of the quark.
To make this more clear the relation to the right of equation \eqref{01b} yields
\begin{equation}
\ol{\bl\zeta}\e\ol{\zeta_1}\,\ol{\bl u\Vp{\bl d}}\p \ol{\zeta_2}\,\ol{\bl d}\quad\bl\implies\quad \ol{\bl\zeta}\e \ol{\plr{\m\zeta_2}}\plr{\bl\m\ol{\bl d}}\p\ol{\zeta_1}\,\ol{\bl u\Vp{\bl d}}\bl\equiv\underbrace{
\begin{bmatrix}
\ol{\plr{\m\zeta_2}} \vp\\
\ol{\zeta_1} \vp
\end{bmatrix}}_{{\lbrace \bl\m\ol{\bl d},\ol{\bl u\Vp{\bl d}}\rbrace}}
\tl{08}
\end{equation}
and
\begin{equation}
\ol{\bl\zeta'}\e\ol{\zeta'_1}\,\ol{\bl u\Vp{\bl d}}\p \ol{\zeta'_2}\,\ol{\bl d}\quad\bl\implies\quad \ol{\bl\zeta'}\e \ol{\plr{\m\zeta'_2}}\plr{\bl\m\ol{\bl d}}\p\ol{\zeta'_1}\,\ol{\bl u\Vp{\bl d}}\bl\equiv\underbrace{
\begin{bmatrix}
\ol{\plr{\m\zeta'_2}} \vp\\
\ol{\zeta'_1} \vp
\end{bmatrix}}_{{\lbrace \bl\m\ol{\bl d},\ol{\bl u\Vp{\bl d}}\rbrace}}
\tl{09}
\end{equation}
$\hebl$
ADDENDUM
For the quark model of mesons consisting of two quarks $\;\bl u\;$ and $\;\bl d$, see my answer here
What is the symmetry of the pion triplet (π−,π0,π+)?, $\color{blue}{\textbf{Example C}}$.
For convenience we repeat the main equations of the mesons
\begin{equation}
\begin{array}{ccccccccc}
&\boldsymbol{\lbrace}\boldsymbol{u},\boldsymbol{d}\boldsymbol{\rbrace} \!\!\!\!\!&\boldsymbol{\otimes}& \!\!\!\!\boldsymbol{\lbrace}\OSB{\boldsymbol{u}},\overline{\boldsymbol{d}}\boldsymbol{\rbrace} & \!\!\boldsymbol{=}\!\! &
\boldsymbol{\lbrace}\boldsymbol{\omega}\boldsymbol{\rbrace}& \!\!\!\!\boldsymbol{\oplus}\!\!&\boldsymbol{\lbrace}\BoldExp{\boldsymbol{\pi}}{-},\BoldExp{\boldsymbol{\pi}}{0},\BoldExp{\boldsymbol{\pi}}{+}\boldsymbol{\rbrace} & \\
& \boldsymbol{2}\!\!\!\!\! & \boldsymbol{\otimes} & \!\!\!\!\OSB{\boldsymbol{2}} & \!\!\boldsymbol{=}\!\!&\boldsymbol{1}&\!\!\!\!\boldsymbol{\oplus}\!\!&\boldsymbol{3}&
\end{array}
\tl{A-01}
\end{equation}
\begin{align}
&\left\{ \boldsymbol{\omega} = \sqrt{\tfrac{1}{2}}\left(\boldsymbol{u}\OSB{\boldsymbol{u}}+\boldsymbol{d}\overline{\boldsymbol{d}} \right)\hphantom{=\,}\right\} \quad \,\text{the singlet }\boldsymbol{1}
\tl{A-02.1}\\
&\left.
\begin{cases}
\BoldExp{\boldsymbol{\pi}}{-} =\boldsymbol{d}\OSB{\boldsymbol{u}} \\
\BoldExp{\boldsymbol{\pi}}{0} =\sqrt{\tfrac{1}{2}}\left(\boldsymbol{u}\OSB{\boldsymbol{u}}-\boldsymbol{d}\overline{\boldsymbol{d}} \right)\\
\BoldExp{\boldsymbol{\pi}}{+} =\boldsymbol{u}\overline{\boldsymbol{d}}
\end{cases}\right\}\quad \text{the triplet }\boldsymbol{3}
\tl{A-02.2}
\end{align}
In the above link we could see the details of the application of a special unitary transformation $\;^{\bl 2}U\in \mr{SU}\plr{2}\;$ on the Hilbert space of the quarks $\;\mathsf Q$
\begin{equation}
^{\bl 2}U \equiv
\begin{bmatrix}
\:\:\:g\hphantom{\boldsymbol{-}}\vphantom{\dfrac12} & h \vphantom{\dfrac12}\:\:\:\\
\!\!\!\!\!\boldsymbol{-}\overline{h} & \OSB{g}\vphantom{\dfrac12}\:\:
\end{bmatrix}\,,
\qquad g\OSB{g}+h\overline{h}=\vert g \vert ^{2} + \vert h \vert ^{2} = 1
\tl{A-03}
\end{equation}
the special unitary transformation $\;^{\bl 4}U\in \mr{SU}\plr{4}\;$ on the product space $\;\mathsf Q\ox\ol{\mathsf Q}$, product itself of $\;^{\bl 2}U\;$ and $\;^{\bl 2}\ol U$
\begin{equation}
\begin{split}
^{\bl 4}U & \e \biggl(\,^{\bl 2}U\biggr)\ox\biggl(\,^{\bl 2}\ol U\biggr) \e\underbrace{\begin{bmatrix}
\:\:\:g\hphantom{\boldsymbol{-}}\vphantom{\dfrac12} & h \vphantom{\dfrac12}\:\:\:\\
\!\!\!\!\!\boldsymbol{-}\overline{h} & \OSB{g}\vphantom{\dfrac12}\:\:
\end{bmatrix}}_{{\lbrace\bl u,\bl d\rbrace}}
\boldsymbol{\otimes}
\underbrace{\begin{bmatrix}
\:\:\:\OSB{g}\hphantom{\boldsymbol{-}}\vphantom{\dfrac12} & \overline{h} \vphantom{\dfrac12}\:\:\:\\
\!\!\!\!\!\boldsymbol{-}h & g\vphantom{\dfrac12}\:\:
\end{bmatrix}}_{\lbrace\ol{\bl u\Vp{\bl d}},\ol{\bl d}\rbrace}\\
&\e
\underbrace{\begin{bmatrix}
\hp\m g\,\ol{g\Vp h} & \hp\m g\,\ol h & \hp\m h\,\ol{g\Vp h} & \!\!\!h\,\ol h \\
\bl\m g\,h & \hp\m g^{2} & \m h^{2} & hg\\
\m\ol h\,\ol{g\Vp h} & \,\m\ol h^{2} & \hp\m\ol{g\Vp h}^{2} & \OSB{g}\overline{h} \\
\hphantom{\boldsymbol{-}}\overline{h}h & \:\:\boldsymbol{-}\overline{h}g & \:-\OSB{g}h & \:\OSB{g}g
\end{bmatrix}}_{\lbrace\bl u\ol{\bl u\Vp{\bl d}},\bl u\ol{\bl d},\bl d\ol{\bl u\Vp{\bl d}},\bl d\ol{\bl d}\rbrace}\\
\end {split}
\tl{A-04}
\end{equation}
which after a proper transformation of the basis in the product space
\begin{equation}
\bl\lbrace\bl u\ol{\bl u\Vp{\bl d}},\bl u\ol{\bl d},\bl d\ol{\bl u\Vp{\bl d}},\bl d\ol{\bl d}\bl\rbrace \quad \bl{-\!\!\!-\!\!\!\longrightarrow}\quad \boldsymbol{\lbrace}\bl\omega,\BoldExp{\boldsymbol{\pi}}{-},\BoldExp{\boldsymbol{\pi}}{0},\BoldExp{\boldsymbol{\pi}}{+}\boldsymbol{\rbrace}
\tl{A-05}
\end{equation}
is transformed to the irreducible direct sum $\;^{\bl 1}U_{\bl{\blr{1}}}\bl\oplus\,^{\bl 3}U_{\bl{\blr{2}}}\;$
\begin{equation}
^{\bf 4}\OSS{U}\!\e
\begin{bmatrix}
\begin{array}{c|ccc}
\:\: 1 \:\: &\rule [0ex]{20pt}{0.0ex}&\rule [-2.5ex]{0pt}{6.0ex} \rule [0ex]{16pt}{0ex}& \rule [0ex]{16pt}{0ex}\\
\hline
\rule [-3ex]{0pt}{6ex}&g^{2} & \boldsymbol{-}\sqrt{2}gh &\boldsymbol{-}h^{2} \\
\rule [-3ex]{0pt}{6ex}& \sqrt{2}g\overline{h} & \left(g\OSB{g}\boldsymbol{-}h\overline{h}\right) & \sqrt{2}\OSB{g}h \\
\rule [-3ex]{0pt}{6ex}& \boldsymbol{-}\overline{h}^{2} & \boldsymbol{-}\sqrt{2}\OSB{g}\,\overline{h} & \OSB{g}^{2}
\end{array}
\end{bmatrix}
=
\begin{bmatrix}
\begin{matrix}
\begin{array}{c|ccc}
^{\bl 1}U_{\bl{\blr{1}}} \:\: &\rule [0ex]{20pt}{0.0ex}&\rule [-2.5ex]{0pt}{6.0ex} \rule [0ex]{16pt}{0ex}& \rule [0ex]{16pt}{0ex}\\
\hline
\rule [-3ex]{0pt}{6ex}&\hp{g^{2}} & \hp{\m\sqrt{2}gh} &\hp{\m h^{2}} \\
\rule [-3ex]{0pt}{6ex}& \hp{\sqrt{2}g\overline{h}} & ^{\bl 3}U_{\bl{\blr{2}}} & \hp{\sqrt{2}\OSB{g}h} \\
\rule [-3ex]{0pt}{6ex}& \hp{\m\overline{h}^{2}} & \hp{\m\sqrt{2}\OSB{g}\overline{h} }& \hp{\OSB{g}^{2}}
\end{array}
\end{matrix}
\end{bmatrix}
\tl{A-06}
\end{equation}