In experimental particle physics at colliders, there are a high number of collisions of incoming particles, for example protons at LHC. Once protons collide in a given collision event, those protons that interact will create one process in the detector. So in one collision, there is one process only. When physicists computing the likelihood to observe, integrated on the huge number of collisions, $n$ events, while expecting (from a theoretical model) $s$ signal events and $b$ background events, one uses the Poisson law:
$$\text{Prob}(n|s+b)=e^{-(s+b)}\frac{(s+b)^n}{n!}.$$
So $n$ is the total events really observed in the detector after several collisions. $s$ is the total events of the signal process that theory model predicts after several collisions. $b$ is the total events of the background process that theory model predicts after several collisions.
The question is: why actually are we allowed to use the Poisson formula?
The Poisson formula is expected to be valid for rare events. But here, there is no probability that enters in the problem. So what is rare ?
See : https://en.wikipedia.org/wiki/Poisson_distribution#Law_of_rare_events
$s$ is rare by definition, but $b$ is not rare: at each collision, we get mostly background events, so $b$ is not rare.
So why could we use Poisson law ? And what is rare?