We happen to live in a universe where today we know space is throughout permeated by quantum fields, which includes the respective field of the muon, and its decay products, the electron and neutrinos. You can think of the muon as the excitation of its respective field, a manifestation of energy stored in the quantum field. This form of energy can transform into other forms of energy if the laws of physics allows. Since to our knowledge the laws allow for the muon to decay, it will do so at a certain probability, and will transform into its decay products.
Muon decay almost always produces at least three particles, which must include an electron of the same charge as the muon and two types of neutrinos.
https://en.wikipedia.org/wiki/Muon
Since vacuum is not empty, and quantum fields can couple to each other, the muon can transform into other forms of excitations in other fields.
We think about particle decay in terms of couplings of quantum fields to each other: an excitation in one field can decay into excitations in others.
Why are muons considered to be elementary particles in the Standard Model?
You say time will lose its meaning in an otherwise empty universe, but I do not think time will lose its meaning, since the muon itself is a quantum mechanical clock if you will.
Since the quantum fields permeate all of space, including the deepest intergalactic voids of space, this decay will happen everywhere in the universe, even in an empty region (and I assume your question is about this), where no other forms of clusters of matter exist, even as your question states, not even a single other particle (excitation). Bottom line, the void of empty space is not empty, it is permeated by all the quantum fields, and since to our knowledge the laws of physics are the same everywhere in the known universe, this together with the probabilistic nature of QM is enough for the decay to happen.