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If use $E=mc^2$ in chemical energy like needs to bonding and ...  it means there must reduced or added some mass after reaction, by Wikipedia mass-energy equivalence:

Because the speed of light is a large number in everyday units, the formula implies that even an everyday object at rest with a modest amount of mass has a very large amount of energy intrinsically. Chemical reactions, nuclear reactions, and other energy transformations may cause a system to lose some of its energy content to the environment (and thus some corresponding mass), releasing it as the radiant energy of light or as thermal energy.

So I would like to know what kind of elementary particle are candidates for the chemical reaction mass change.

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    $\begingroup$ you say:releasing it as the radiant energy of light or as thermal energy ., so the particles are photons $\endgroup$ – trula Apr 4 '20 at 10:23
  • $\begingroup$ This may be helpful: en.wikipedia.org/wiki/Binding_energy $\endgroup$ – PM 2Ring Apr 4 '20 at 11:10
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Chemical reactions can be described fully in terms of electrons, (given) nuclei and sometimes photons.

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