In Lagrangian mechanics, it is possible to multiply the Lagrangian by a constant $a$. Let's assume I take $a=-1$.
Then, the Hamiltonian will have its sign changed as well. And it will represent the good dynamic as well.
What I don't understand is the possible energy interpretation we can have of the Hamiltonian. If $H$ and $-H$ are physically equivalent, how to know what is the lowest energy of a system?
How to make connection with statistical mechanics for example (canonical probabilities).
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Let's say everything is classical, consider for example a classical Ising Hamiltonian: $H=J S_1 S_2$ with $J>0$. In one description the fundamental would be $++$ or $--$, in the other, $+-$ or $-+$. The physical description are thus different in term of statistical physics.
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I think that @knzhou is indeed the good one but something is still perturbing me. If someone gives you those two equivalent hamiltonian: $H=J S_1 S_2$ and $H'=-J S_1 S_2$
You want to know what is the occupied state at $0K$. Conceptually would you agree it is absolutely impossible to know what it will be, you could state ($++$,$--$), or ($+-$ or $-+$) because the formalism is symmetric via $H \rightarrow -H$.
Then to know what in practice you will see you must do an experiment. This experiment will tell you which sign to choose so that it matches statistical physics description. It is impossible to know theoretically what it will be.
If no experiment are needed it necesserally mean that I need an extra mathematical axiom in addition to hamiltonian formalism to do this mapping. If so, which one ?