Dirac thought large numbers shouldn't exist at all in physics, on purely aesthetic grounds. After all, "where would such a number come from?" Today this criterion is known as "Dirac naturalness".
You might have heard about naturalness in the press, but few practitioners actually use Dirac's original form, because we know it's not very reliable. For example, the phenomenon of dimensional transmutation can be used to automatically create enormous numbers from normal-sized inputs, and that is how the smallness of the proton mass is explained. The other reason is that Dirac naturalness is very difficult to test, because if a large number is "technically natural", then it can be embedded in a Dirac natural theory by new physics that appears at extremely high energies. (For context see here and here.) This means we usually can't easily "cash out" Dirac naturalness into hypotheses that we can test this millennium, besides the cosmological ones that have already been shown false. Any scientific hypothesis that can't be tested in a thousand years is, of course, completely uninteresting.
However, if you do take Dirac's point of view, saying that two large numbers are equal reduces the number of large numbers you have to explain, thereby making the theory "more natural". That's the motivation behind the hypothesis.
It's easy to criticize this aesthetic idea as being subjective, and hence unscientific, but that's not right. In school we are taught that science progresses by proposing hypotheses, testing them, and then refining them. There is little attention devoted to how hypotheses are created in the first place. This process is necessarily subjective.
You might say that instead of beauty, one should instead try the simplest hypothesis first, or the one that looks the most sensible. Both of these are, however, also completely subjective. Even simplicity is subjective because a hypothesis can be very complex or the simplest possible one depending on the formalism you choose to work in. And there is nothing inherently wrong with numerology; if it works, it's called discovery. Many of the greatest discoveries in physics, such as Newton's inverse square gravity and Maxwell's electromagnetic waves, were made in precisely this way.
We should think of Dirac's large numbers hypothesis as an interesting guess with a real scientific motivation, which just didn't pan out. 99% of all fundamental physics doesn't, that's the way it's always been, and that's how it must be, since we don't know ahead of time what the 1% will be.