Is charge point-like or a smear? Coulomb gave the law for the force between two static charges while considering them to be points in space. But the differential form of Gauss' Law talks about charge densities, a thing possible only if charges are smeared out in space. 
Even Feynman addresses to the problem in his lectures when he says that on solving for the electrostatic energy in the field of a point charge we get infinity as the limit.
So do we know now that whether charges are point-like or smeared out?
 A: 
But the differential form of Gauss' Law talks about charge densities, a thing possible only if charges are smeared out in space.

Actually differential Gauss' law is valid even for point charges. For point charge $q$ at point $\mathbf x_0$, instead of charge density, we use charge distribution $\rho(\mathbf x) = q\delta(\mathbf x-\mathbf x_0)$.

Even Feynman addresses to the problem in his lectures when he says that on solving for the electrostatic energy in the field of a point charge we get infinity as the limit.

That problem is a separate question. There are consistent theories both for point and extended charges with finite energy in both cases. Neither kind of theory can supply us with hint on whether real particles are points or extended bodies. This must be investigated by experiments.

So do we know now that whether charges are point-like or smeared out?

For electrons, we don't know; all experiments are consistent with point particle, but it can be extended body of small enough size. The current decades old limit on electron size is somewhere near 1e-18 m.
For protons, based on scattering experiments and their understanding in terms of quantum theory of scattering, these are believed to have non-zero size (of charge distribution) around 1e-15 m.
A: It depends on scale.
Electrons can usually be viewed as point-like when viewed on a scale much larger than an individual atom.
But semiconductors often have on the order of $10^{12}- 10^{23}$ free electrons per ${\rm cm^{3}}$, depending on temperature and doping. Copper, as an example of a metal, has about $10^{23}$ free electrons per $\rm cm^3$. 
In these materials, if the volume you're considering is even a few $\rm \mu m^3$, the error produced by assuming the charge is smeared out instead of localized in thousands or trillions of points is very small.
If you're studying some system with only a few charge carriers present, then you might need to consider the charge to be localized to make accurate predictions about it.
A: It's not a trivial matter to define this question in such a way that it has a definite answer, and you certainly can't get a good answer within classical physics.

Even Feynman addresses to the problem in his lectures when he says that on solving for the electrostatic energy in the field of a point charge we get infinity as the limit.

Yes, this is a nice way approaching the issue. Now consider that classical electromagnetism is inherently a relativistic theory, so $E=mc^2$ applies. For a particle with mass $m$, charge $q$, and radius $r$, we would expect that the inertia $m$ of the particle can't be greater than $\sim E/c^2$, where $E$ is the energy in the electric field. This results in $r\gtrsim r_0=ke^2/mc^2$, where $r_0$ is called the classical electron radius, although it doesn't just apply to electrons.
For an electron, $r_0$ is on the order of  $10^{-15}$ meters. Particle physics experiments became good enough decades ago to search for internal structure in the electron at this scale, and it doesn't exist, in the sense that the electron cannot be a composite particle such as a proton at this scale. This would suggest that an electron is a point particle. However, classical electromagnetism becomes an inconsistent theory if you consider point particles with $r\lesssim r_0$.
You can try to get around this by modeling an electron as a rigid sphere or something, with some charge density, say a constant one. This was explored extensively ca. 1900, and it didn't work. When Einstein published the theory of special relativity, he clarified why this idea had been failing. It was failing because relativity doesn't allow rigid objects. (In such an object, the speed of sound would be infinite, but relativity doesn't allow signaling faster than $c$.)
What this proves is that if we want to describe the charge and electric field of an electron at scales below $r_0$, we need some other theory of nature than classical E&M. That theory is quantum mechanics. In nonrigorous language, quantum mechanics describes the scene at this scale in terms of rapid, random quantum fluctuations, with particle-antiparticle pairs springing into existence and then reannihilating.
A: Electrons are considered point charges. Protons have a radius somewhat smaller than a femtometer. There is a controversy over the precise value of the proton radius. So a proton can be considered a smear, albeit a very tiny one. 
