Easily observable features (i.e. without the need for any
telescopes) are the north pole and south pole of the sky.
These are the points in the sky around which all stars seem
to rotate during their nightly course.
Currently the north pole of the sky is near the star Polaris
($\alpha$ Ursae Minoris).
But due to the precession of the equinoxes this is changing
slowly through the millennia.
The north pole of the sky circles around the ecliptic pole in 23.5°
distance once in 25772 years.
The timeline of the north pole from 10000 BC to 14000 AD looks like this (notice the "Polaris" star near the "+2000" mark):
image from Precession of the equinoxes - Changing pole stars
Another long-term effect changing the apparent positions of the stars
in the sky is their proper motion.
The stars move slowly (mostly with speeds of a few milliarcsecond/year)
across the sky relative to the background of the more distant stars.
Here is how the constellation Ursa Major (i.e. the Great Bear)
looks now and 100000 years from now.
image from astropixie: ursa major