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I guess this depends on what you mean by "artificially overcome." E.g., as pointed out in a comment, this could include nuclear fission. If "overcome" means to cancel the strong nuclear force using some other externally applied force, then your externally applied force would have to do the amount of work that was released. So you'd just be getting back out the energy you put in.
In general when posting questions here, it's a good idea to try to think them through and research them as much as possible, rather than asking this kind of vague and wide-open question.