Simple explanation of the QCD VEV in terms of instantons I've heard that instantons in QCD generate quark bilinear condensate $\langle \bar{q}_{L}q_{R}\rangle$ which is responsible for spontaneous symmetry breaking. Is there any clear and simple way to explain this? 
 A: Short answer: Instantons explain chiral symmetry breaking qualitatively (and semi-quantitatively) in strongly coupled gauge theories such as QCD, and quantitatively in certain cousins of QCD. 
Instantons have fermion zero modes (as a consequence of the index theorem), and 't Hooft explained that the effect of zero modes on correlation functions can be summarized in terms of an effective vertex
$$
 {\cal L } \sim \det_f (\bar\psi_L^f\psi_R^g) + {\it h.c.}
$$
where $f,g$ are flavor indices. In $N_f=1$ QCD this directly generates $\langle\bar\psi_L\psi_R\rangle$, but the overall coefficient cannot be reliably determined. 
In theories with $N_f>1$ the 't Hooft vertex directly generates condensates of the form $\langle(\bar\psi_L\psi_R)^{N_f}\rangle$. In some cases, the overall coefficient can be determined, see, for example this work. 
The 't Hooft vertex in theories with $N_f>1$ can be understood as generating an effective Nambu-Jona-Lasinio model. Take $N_f=2$. Then 
$$ 
{\cal L} \sim G (\bar\psi_L\psi_R)^2 +  \ldots
$$
which is known to spontaneously break chiral symmetry beyond some critical coupling $G$ (as explained in many papers, this is easily seen using the mean field approximation or Dyson-Schwinger equations). We cannot reliably compute $\langle\bar\psi_L\psi_R\rangle$, beacuse $G$ is sensitive to large instantons (and strong coupling), and the NJL model is non-renormalizable (it requires a cutoff). A more microscopic picture of how instantons break chiral symmetry follows from the Casher-Banks relation, and the existence of fermion zero modes, see here. 
For $N_f>2$ the effective 't Hooft vertex is not of the standard (4-fermion) NJL-model form, but in the mean field approximation 6 (and higher) fermion langrangians can also lead to spontaneous symmetry breaking. There are reasons to believe that there is a critical $N_f$ (smaller than the critical $N_f$ where asymptotic freedom disapears) beyond which chiral symmetry is unbroken. 
QCD with realistic quark masses is intermediate between $N_f=2$ and $N_f=3$. The effective lagrangian is of the form
$$ 
{\cal L} \sim G_s m_s (\bar u_L u_R)(\bar d_L d_R) + G(\bar\psi_L\psi_R)^3   + \ldots
$$
and it is not apriori clear which of the two terms is more important.
There are some QCD-like model, where chiral symmetry breaking and instantons can be studied reliably, see this work. 
