In the context of canonical quantization, the ground state/zero-point energy of a harmonic oscillator is $$ E_0 = \frac{1}{2}\hbar \omega. $$ The vacuum is alleged to be permeated with this zero-point energy of quantum fields, hence causing the exorbitantly large cosmological constant issue.
However, the zero-point energy can be normal ordered away (Wick ordering). And path integral formulation automatically takes care of normal ordering. In other words, path integral formulation (and normal ordering canonical quantization) doesn't suffer from the zero-point energy issue.
The Casimir effect is usually cited as an evidence of zero-point energy. Nevertheless, a 2005 paper (https://arxiv.org/abs/hep-th/0503158v1) states that "Casimir forces can be computed without reference to zero-point energies...The Casimir force is simply the (relativistic, retarded) van der Waals force between the metal plates".
So is zero-point energy a spurious artifact of canonical quantization?
Note that in the absence of zero-point energy, the cosmological constant problem still stands because of the vacuum energy shift resulted from spontaneous electroweak symmetry breaking.