In Eddington Finkelstein Coordinates: Lecture By Emil Akhmedov at 7:10 (transcript below the video) the instructor mentions in passing that on general grounds, Einstein's theory of general relativity can only be expected to apply where the curvature is small, but he doesn't go into further detail.
Why is that? Is there a physical reason why we should expect that?
EDIT What he says is this (slightly adapted from the transcript):
... this tensor measures the strength of tidal forces, and they become enormous as $r$ goes to zero. That's the reason that this metric is applicable only beyond this point. Moreover, one can say that Einstein's general theory of relativity is not applicable as $r$ goes to zero anymore, because higher terms and powers of curvature are becoming relevant. So the curvature becomes strong. And Einstein's theory on general grounds can be expected to be applicable only if curvature is small, sufficiently small.
He seems to be saying that the Schwarzschild geometry ceases to be applicable for $r\to 0$ not only because $R_{\mu\nu\alpha\beta}R^{\mu\nu\alpha\beta} \to \infty$, but also because more generally the theory is only applicable when the curvature is small. The fact that he speaks about higher powers of the curvature seems to indicate that general relativity is just a first order approximation of a more general theory.
EDIT 2
I asked on the course forum, where I only got two views but one of them was the lecturer's. Essentially what he was alluding to was what @gj255 already said in the comments:
It is an assumption, if you think about it more carefully. We have assumed the simplest invariant - $R$ - as the Lagrangian density, but why not $R^2$ e.g.? If you look at this, you will realize that $R^2$, or even higher powers of Ricci scalar or tensor or Riemann tensor, become more relevant, as $r\to 0$, because then curvature tends to infinity...
To give some context: in the derivation of the Einstein equations in this course, an invariant Lagrangian density depending on the metric was constructed. The simplest possible term, $\sqrt{|g|}$ cannot account for any dynamics. Adding the term $\sqrt{|g|}R$ we get dynamical equations of motion and the relative coefficient between these terms is the cosmological constant. This is where he stopped, but apparently there is no a reason why we should, and apparently we should expect non-zero higher order contributions.