With the proper definition of the "size" of the universe, this question does make sense. The standard model of cosmology would say that the universe is infinite which therefore does not have a "size". However, if we take into account that the big bang occurred $13.7 \pm 0.17$ billion years ago we can define a meaningful size for the observable universe. You might, for example, define the size of the observable universe as the distance a photon could have traveled since the big bang.
Consider, for example, a cosmic microwave background (CMB) photon that was emitted as visible light about 379,000 years after the big bang and is just now hitting our microwave detectors (the redshift is z=1089): that photon has been traveling for 13.7 billion years so it has traveled a distance of 13.7 billion light years. So you might imagine that the current radius of the observable universe is 13.7 billion light years. However, during this time the universe has been expanding, so the current position of the matter that emitted that photon will now be 46.5 billion light years away. (By now, the little $10^{-5}$ bumps on the CMB will have condensed into galaxies and stars at that distance.) This gives a diameter of the current observable universe of 93 billion light years. Note that as time passes, the size of the observable universe will increase. In fact it will increase by significantly more than two (to convert radius to diameter) light years per year because of the continued (accelerating) expansion of the universe. Also note that we will not be able to use photons (light) to explore the universe earlier than 379,000 years after the big bang since the universe was opaque to photons at that time. However, in the future we could conceivably use neutrinos or gravitational wave telescopes to explore the earlier universe.
So given a size of the current observable universe, we can ask how big was that volume at any particular time in the past. According to this paper at the end of inflation the universe's scale factor was about $10^{-30}$ smaller than it is today, so that would give a diameter for the currently observable universe at the end of inflation of 0.88 millimeters which is approximately the size of a grain of sand (See calculation at WolframAlpha).
It is believed that inflation needed to expand the universe by at least a factor of 60 e-foldings (which is a factor of $e^{60}$). So using WolframAlpha again we find that the diameter of the universe before inflation would have been $7.7 \times 10^{-30}$ meters which is only about 480,000 Planck lengths.
Perhaps Brian Greene was talking about the size of the observable universe at the time when the CMB photons started traveling towards us. That happened 379,000 years after the big bang at a redshift of 1098 which means the universe was about 84.6 million light years in diameter which, per WolframAlpha, is about half the diameter of the local super cluster of galaxies or about 840 times the diameter of our galaxy.