For capacitors in series: the same current flows through both of them for the same time. So the electric charge Q is the same on each of the capacitors.
Use the capacitor formula Q = CV to calculate the potential on each capacitor in terms of the unknown but equal Q's.
These 2 voltages add up to the applied voltage.
For example if one capacitor is 4x the size of the other; then you will discover that the smaller capacitor has 4x the voltage as the larger capacitor.
If the applied potential is 250v then the large capacitor has 50V and the small has 200V.
In very high voltage circuits one is sometimes forced to use a set of equal capacitors in series as a smoothing circuit; to remove hum.
It is imperative to connect high resistance resistors (say 100 M ohms) across each of the capacitors, to equalize the leakage currents and ensure that the capacitors share the high potential equally.
To answer your question: Connect the capacitors in series and place your load resistor across the two ends. Current will flow until one of the capacitors is empty with zero volts across it. But the voltage on the remaining capacitor will keep current flowing so the empty capacitor receives a reverse charge; thus developing a negative voltage. When the positive and negative voltage become equal; the current ceases to flow and the charges can be calculated using the starting conditions and Q = CV keeping in mind that the same current has flowed through both for the same time giving the same change in Q. Set up the simultaneous equations and solve them to get your voltage and your charges. PS: always draw a Before and After diagram with the appropriate values - known and unknown - so that you can easily see what the equations should be.