Fusion of nuclei inside stars switches from exothermic to endothermic for Iron and elements heavier than Iron. Supernovas not only achieve fusion of transuranides (albeit in trace relative quantities), but they also release a huge excess of energy that is comparable to the fusion energy generated during its whole lifetime
How well do we understand the mechanism that causes this huge mass-energy conversion?
Also, considering that fission releases 0.1% at most of rest mass, and fusion releases 1% at most, what is the fraction of mass-energy that is converted by the underlying mechanism in supernovas?