Does metric signature affect the stress energy tensor? If one were to derive the stress-energy tensor for a metric with $(+,-,-,-)$ signature would it be different from the stress-energy tensor derived from the same metric but with $(-,+,+,+)$ signature?
 A: The straight answer to your question is no, the value of the components of the stress energy tensor do not change according to the metric signature.
Qmechanich showed you how the formulas change, depending on the metric signature, just in order to keep the component values the same. 
A: *

*The sign convention for the stress-energy-momentum (SEM) tensor $T^{\mu\nu}$ is usually chosen such that the energy density $T^{00}$ (or $T_{00}$) is positive.
The sign convention for the action is usually chosen such that the kinetic term is positive.


*This implies that the Hilbert/metric SEM tensor is defined as
$$ T^{\mu\nu}~:=~\pm \frac{2}{\sqrt{|g|}}\frac{\delta S}{\delta g_{\mu\nu}}, \qquad T_{\mu\nu}~:=~\mp \frac{2}{\sqrt{|g|}}\frac{\delta S}{\delta g^{\mu\nu}},\tag{M}$$
for Minkowski (M) sign convention $(\mp,\pm,\pm,\pm)$, respectively.
For Euclidean (E) sign convention $(+,+,+,+)$, it is
$$ T^{\mu\nu}~:=~ -\frac{2}{\sqrt{g}}\frac{\delta S}{\delta g_{\mu\nu}}, \qquad T_{\mu\nu}~:=~ \frac{2}{\sqrt{g}}\frac{\delta S}{\delta g^{\mu\nu}}.\tag{E}$$
