In the standard model of particle physics, there are three generations of quarks (up/down, strange/charm, and top/bottom), along with three generations of leptons (electron, muon, and tau). All of these particles have been observed experimentally, and we don't seem to have seen anything new along these lines. A priori, this doesn't eliminate the possibility of a fourth generation, but the physicists I've spoken to do not think additional generations are likely.
Question: What sort of theoretical or experimental reasons do we have for this limitation?
One reason I heard from my officemate is that we haven't seen new neutrinos. Neutrinos seem to be light enough that if another generation's neutrino is too heavy to be detected, then the corresponding quarks would be massive enough that new physics might interfere with their existence. This suggests the question: is there a general rule relating neutrino masses to quark masses, or would an exceptionally heavy neutrino just look bizarre but otherwise be okay with our current state of knowledge?
Another reason I've heard involves the Yukawa coupling between quarks and the Higgs field. Apparently, if quark masses get much beyond the top quark mass, the coupling gets strong enough that QCD fails to accurately describe the resulting theory. My wild guess is that this really means perturbative expansions in Feynman diagrams don't even pretend to converge, but that it may not necessarily eliminate alternative techniques like lattice QCD (about which I know nothing).
Additional reasons would be greatly appreciated, and any words or references (the more mathy the better) that would help to illuminate the previous paragraphs would be nice.